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An unexpected discovery on the liver

To refine their analysis, Pierre Maechler and colleagues reintroduced a functional OPA1 protein in mice in which it had previously been deleted. "" the scientists say. ""

However, the greatest surprise was yet to come. ""super-mitochondria,"" enthuses Pierre Maechler. This study therefore undermines the long-held for 1 last update 02 Jul 2020 belief that the production of glucose by the liver necessarily depends on external stimuli.However, the greatest surprise was yet to come. ""super-mitochondria,"" enthuses Pierre Maechler. This study therefore undermines the long-held belief that the production of glucose by the liver necessarily depends on external stimuli.

This is the first time that glucose production by the liver has been observed independently of an external signal, and particularly hormonal. This finding may explain the development of type 2 diabetes in patients with a "" syndrome, apart from any apparent insulin imbalance. To confirm this, UNIGE researchers are now considering modifying the morphology of liver cell mitochondria in overweight mice to see if this overproduction of glucose can trigger abnormally high blood sugar levels and therefore diabetes

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Materials provided by Université de Genève. Note: Content may be edited for style and length.

Journal Reference:

  1. Lingzi Li, Juliette Martin-Levilain, Cecilia Jiménez-Sánchez, Melis Karaca, Michelangelo Foti, Jean-Claude Martinou, Pierre Maechler. In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way. Journal of Biological Chemistry, 2019; 294 (34): 12581 DOI: 10.1074/jbc.RA119.007601

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Université de Genève. "" ScienceDaily. ScienceDaily, 11 September 2019. <www.sciencedaily.com/releases/2019/09/190911101527.htm>.
Université de Genève. (2019, September 11). Type 2 diabetes is not just about insulin. ScienceDaily. Retrieved May 12, 2020 from www.sciencedaily.com/releases/2019/09/190911101527.htm
Université de Genève. "" ScienceDaily. www.sciencedaily.com/releases/2019/09/190911101527.htm (accessed May 12, 2020).



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